Endocrine Abstracts

Background: numerous studies using a variety of quality of life (QOL) measures have shown multiple impairments in adults with growth hormone deficiency (GHD) compared to control subjects. There have been few studies however of QOL in a treated GHD population compared with healthy controls.Method: 120 adults with treated GHD ( >1 year) were given the following QOL questionnaires at annual review: SF36, Nottingham Health Profile, Disease Impact, Life F...

Background: We previously demonstrated that elderly patients with GHD have increased and young GHD patients have reduced cardiac sympathovagal balance. Therefore we decided to investigate whether the relationship between age and cardiac sympathovagal balance is altered in GHD compared to healthy controls.Method: HRV, which indirectly measures cardiac sympathovagal balance, was measured in 22 untreated GHD patients (13 F; mean age 47.4 yrs; range 19-73 y...

OBJECTIVE: To assess the impact of untreated growth hormone deficiency (GHD) over 2 yrs in elderly patients with hypothalamic-pituitary disease. Controls were also followed for 2 yrs.SUBJECTS: 27 patients (>65 yrs) with GHD (mean) peak stimulated GH 1.6 mIU/l(range 0.6-5)were initially studied. Two yrs later 21(13 males) agreed to attend for reassessment. 27 controls (>65 y) were studied at baseline and 17 (7 males) agreed to attend for reassessmen...